While much has been learned about literacy in the elementary grades, less is known about programmatic approaches that help struggling adolescent readers acquire the skills they need to succeed in high school. The Enhanced Reading Opportunities Study tests the effectiveness of two supplemental literacy interventions targeted to ninth-grade readers with reading comprehension skills that are two to four years below grade level. The interventions studied are (1) Reading Apprenticeship for Academic Literacy from WestEd and (2) Xtreme Reading from the University of Kansas Center for Research on Learning.